Marcelo Bielsa's men have struggled to replicate their form of last season and currently languish in the lower reaches of the table.
Los Leones have no new injury worries ahead of the match, but a number of the first team are in danger of earning an automatic suspension.
Diego Simeone has guided his team seven points clear of cross-city rivals Real Madrid, who are chasing in third place.
Bilbao: Iraizoz; Aurtenetxe, Amorebieta, San Jose, Iraola; Iturasspe, De Marcos, Herrera, Muniain, Susaeta; Lopez
Atletico: Courtois; Godin, Luis, Juanfran, Miranda; Tiago, Koke, Turan, Gabi; Costa, Falcao
Sports Mole says: 2-1