The world number two plays the Spaniard in the quarter-final of Wimbledon and he claimed that regularly playing his sibling means that he will be able to alter his game accordingly.
"I grew up playing with my brother, Jamie, so it doesn't normally take me that long to adjust [to left-handers]," Murray is quoted as saying in The Guardian.
"I don't mind playing left-handers. It's just the serve that takes me a while. Playing a left-hander is the same on pretty much all surfaces.
"But playing on clay, the topspin they put on the ball, especially on the serve, is different to grass because, on grass, the ball slides through the court more and so it comes away from you."