That saw Wolves fall out of the top six and on Tuesday they will be without a victory in the league for over a month.
As for Boro, they come into the game just a point adrift of table-toppers Watford in third place and haven't suffered defeat since the end of August.
Aitor Karanka's side are on a seven-game unbeaten run and have won five of those matches to close in on the summit.
On Saturday they recorded their fourth away win of the season - only Norwich City have won as many on the road - at Brighton & Hove Albion to make it two wins on the spin.
Lee Tomlin scored the opening goal at The Amex, but was then forced off at half time with a leg injury and might have to sit out the trip to Molineux.
If Tomlin does have to miss out, then Jelle Vossen is the most likely to replace him in the starting XI after he came on in his place at Brighton.
The last time these two sides met was in March 2013, with Wolves coming out on top 3-2.
Possible starting lineups
Wolves: Ikeme, Doherty, Batth, Ebanks-Landell, Rowe, McDonald, Evans, Van La Parra, Edwards, Sako, Dicko
Boro: Konstantopoulos, Fredericks, Ayala, Gibson, Friend, Adomah, Clayton, Leadbitter, Reach, Vossen, Kike
Sports Mole says: 2-1