Despite topping their group in this competition, Espanyol travel to Molineux sitting at the bottom of the La Liga standings.
With the winter break having come at the right time for Wolves after an exhausting few months, Nuno Espirito Santo must now hope that his side can regain some momentum after an indifferent start to the year.
Having faced Liverpool, Leicester City and three games with Manchester United in all competitions, the level of difficulty should be taken into account when making a judgement on a run of just one triumph in nine outings.
Nevertheless, Nuno will feel that his team were capable of prevailing in several of those matches, with the onus now being placed on an attack which has generally misfired over the past six weeks.
Aside from a stunning second-half comeback at Southampton, just three goals have been netted in the other eight matches, something which must improve if the club are to stay in contention for a top-six place in the Premier League and the latter stages of Europe.
However, Wolves have shown in the past that they can quickly go from the frustrating to the sublime, and Nuno will hope that is the case when taking on a team who have improved since the appointment of Abelardo in December.
Despite their lowly league position, Espanyol have lost just twice in eight games since the arrival of the former Barcelona centre-back, which includes nine points coming from six La Liga fixtures.
Draws against Barca and Sevilla have been recorded during that period, highlighting that this represents a tough assignment for Wolves after being handed a favourable draw in the group stages.
Wolverhampton Wanderers Europa League form: LWWWDW
Wolverhampton Wanderers form (all competitions): DLWLDD
Espanyol Europa League form: DWWWDL
Espanyol form (all competitions): WLDLWD
Fellow fresh faces Cabrera and Embarba are in line to start, with right-back Sebastien Corchia the only long-term absentee.
Wolverhampton Wanderers possible starting lineup:
Patricio; Boly, Coady, Saiss; Doherty, Moutinho, Neves, Jonny; Traore, Jimenez, Jota
Espanyol possible starting lineup:
D.Lopez; J.Lopez, L.Lopez, Cabrera, Vila; Lozano, Sanchez; Embarba, Darder, Vargas; Calleri
We say: Wolverhampton Wanderers 2-1 Espanyol
With both teams having shown similar form of late, this is a difficult one to call. However, the atmosphere under the lights at Molineux could prove key for Wolves, who we feel will grind out a narrow win over improving opponents.