The winger has failed to overcome the illness that saw him miss his team's defeat to Cardiff City in midweek.
Wigan have not won any of their four games this season in all competitions, losing the last three.
Blackpool midfielder Jose Cubero is absent for the Seasiders as he is still awaiting international clearance.
Wigan Athletic: Carson Taylor, Ramis, Riera, Huws, McManaman, McArthur, Boyce, Cowie, Perch, Kiernan
Subs: Al Habsi, Barnett, Tavernier, Waghorn, Fortune, Espinoza, Caldwell
Blackpool: Lewis, McMahon, Clarke, Rentmeister, Daniels, J Oriol, Perkins, Lundstram, Zenjov, Zoko, Delfouneso
Subs: Parish, Dielna, E Oriol, MacKenzie, Cywka, Miller, Ranger