Paul Konchesky replaces Ignasi Miquel, who is on loan from Premier League side Arsenal. Danny Drinkwater takes the place of the suspended Matty James, while Jamie Vardy and Lloyd Dyer are also given starting berths.
Meanwhile, the FA Cup holders make just one change to their team from the 2-1 win over Nottingham Forest.
James McCarthy, who has departed for Everton, is replaced by James Perch, who stepped down to the Championship from Premier League side Newcastle United in the summer.
Leicester City: Schmeichel; De Laet, Morgan (c), Moore, Konchesky; Knockaert, Drinkwater, King, Dyer; Nugent, Vardy
Wigan Athletic: Carson, Boyce, Rogne, Barnett, Beausejour, Perch, Watson, Espinoza, Gomez, Maloney, Fortune