Wigan currently sit five points clear of the drop zone in 17th, whereas Stoke are three places below the Latics and only one point above the bottom three after 39 matches.
Wigan continued their remarkable run of form with a 2-0 victory over promotion hopefuls Blackburn Rovers on Saturday – a result which moves them further away from the relegation zone at this crucial stage of the campaign.
Late goals from substitutes Lee Evans and Michael Jacobs stretched Wigan's unbeaten league run to eight matches and maintained their 100% record since the Championship resumed amid the coronavirus pandemic.
Furthermore, Paul Cook's side have now gone six games without conceding a goal in the second tier and are well on course to remain in the division for a third consecutive season.
The three sides above Wigan in Birmingham City, Reading and Queens Park Rangers all failed to win last time out, and Cook's side are now within touching distance of the trio as the fight to avoid relegation to League One hots up.
A victory over Stoke this weekend would take the Latics to the 50-point mark for the season, and considering that Wigan managed to stay up with 52 points during the 2018-19 campaign, their survival prospects for this season are looking all the more promising with seven gameweeks remaining.
In contrast, Stoke's hopes of survival were dealt a huge blow as they succumbed to a 2-0 defeat to fellow strugglers Middlesbrough on home soil.
Neil Warnock enjoyed his first game in the Boro dugout as goals from Ashley Fletcher and Marcus Tavernier brought Stoke's five-game unbeaten run to an end and left the Potters teetering above the drop zone.
Stoke have amassed 43 points from 39 games this season and are only one clear of the bottom three at this stage, although O'Neill would have breathed a huge sigh of relief as 22nd-placed Huddersfield Town, who sit just one point behind the Potters, suffered a 2-0 defeat to Nottingham Forest on Sunday.
Nevertheless, the Potters continue to search for their first three points since the restart following a 1-1 draw with Reading upon the league's resumption, and they have not enjoyed victory on their travels since January.
Wigan Athletic Championship form: WWWDWW
Stoke City Championship form: WDDWDL
Cook has no fresh injury concerns heading into the midweek clash with Stoke.
Evans and Jacobs are both pushing for starting roles following their goals last time out, while Leon Balogun was an unused substitute at the weekend and could play a part here.
As for Stoke, Powell's red card in the defeat to Middlesbrough means that the former Wigan man will not be able to return to the DW Stadium for the midweek clash.
Young Danish midfielder Lasse Sorensen was hauled off before half-time in the defeat to Boro and may lose his place in the starting XI for this one.
Wigan Athletic possible starting lineup:
Marshall; Byrne, Kipre, Balogun, Robinson; Williams, Evans, Morsy; Lowe, Moore, Jacobs
Stoke City possible starting lineup:
Butland; Smith, Batth, Shawcross, Martins Indi; Cousins, Clucas, Thompson; Ince, Vokes, McClean
We say: Wigan Athletic 2-0 Stoke City
Wigan are certainly not playing like a bottom-half side at the moment, and Stoke's confidence would have been rocked by their disappointing loss against Boro at the weekend, so we are backing the Latics to continue their terrific run of form with a comfortable home victory on Tuesday evening.