However, bottom-of-the-table side Luton can reduce the gap to the Latics to just three points with victory at the DW Stadium on Saturday afternoon.
At one stage this season, it appears that Wigan and Luton would be left cut adrift in the relegation zone after hugely disappointing efforts during the first half of the campaign
However, the Latics and the Hatters now have a realistic chance of retaining their second-tier statuses against the odds after their respective recent revivals.
Wigan have recorded five victories and two draws from their last eight league matches, which includes three wins in a row against Millwall, Reading and West Bromwich Albion.
The most recent success at The Hawthorns was all the more impressive due to the absence of key defender Cheyenne Dunkley, who has been ruled out for the rest of the season with a broken leg.
Wigan also have three successive shutouts to their name having previously registered just one in their previous 11 outings.
Much of Luton's success has also come down to a strong backline with just five goals being conceded in as many fixtures, three of which came in the same game against Charlton Athletic.
That defeat at The Valley has proven to be just a minor blip, with three wins and 10 points being recorded from their other four matches.
The most important result of that period arguably came last week as James Collins netted a last-minute penalty to earn a share of the spoils against Stoke City, a result which ensured that the 21st-placed Potters remain just five points ahead of Luton heading into the weekend.
Wigan Athletic Championship form: LDDWWW
Luton Town Championship form: WWWLWD
Should the Brighton & Hove Albion loanee miss out, Kal Naismith is in line to feature in the middle of the defence.
The remainder of the team may remain the same, although Michael Jacobs is pushing for a recall in the final third.
Luton boss Graeme Jones must decide whether he is prepared to play with two in attack for a trip to one of their rivals.
Central midfielder George Moncur is also pushing for just his second league start of the season.
Wigan Athletic possible starting lineup:
Marshall; Byrne, Kipre, Balogun, Pearce; Williams, Morsy; Lowe, Roberts, Massey; Moore
Luton Town possible starting lineup:
Sluga; Cranie, Pearson, Carter-Vickers, Potts; Mpanzu, Rea, Tunnicliffe; Brown, McManaman, Collins
We say: Wigan Athletic 2-1 Luton Town
While you cannot write off Luton in this contest, it is equally hard to back against Wigan right now. Cook's men are third in the Championship form table, and we feel that they will show the cutting edge required to see off the Hatters.