The Latics shocked Manchester City in the final last year but went on to be relegated from the Premier League at the end of the season.
Palace manager Tony Pulis's priority is certainly ensuring that the Eagles do not follow Wigan into the Championship, and therefore several key players could be rested for their trip to Lancashire.
With loanee Cameron Jerome ineligible, Dwight Gayle is likely to lead the Palace attack, while left-back Dean Moxey and midfielders Barry Bannan and Jonathan Williams could also get run outs from the off.
The German, who lost for the first time in his Athletic reign at Doncaster Rovers last weekend, described McEachran's arrival as "a big scoop" and therefore could insert him straight into his starting XI.
Shaun Maloney is still unavailable as he continues rehabilitation from hip surgery, while Ivan Ramis also remains sidelined. Callum McManaman, James Perch and Marc-Antoine Fortune are fighting for recalls.
Possible starting lineups
Wigan: Al-Habsi; Perch, Boyce, Barnett, Beausejour; McArthur, Watson, McEachran, McCann; Powell, Fortune
Palace: Speroni; Mariappa, Gabbidon, Delaney, Moxey; Bolasie, Ward, Guedioura, Williams, Bannan; Gayle
Sports Mole says: 2-1