The Hammers are currently fifth in the division, two points behind fourth-placed Chelsea, while Wolves occupy 13th position, nine points clear of the relegation zone.
There is no getting away from the fact that it has been a disappointing season for Wolves, with a total of 35 points from 29 matches leaving them down in 13th position in the table.
Nuno Espirito Santo's side have finished seventh in each of the last two Premier League campaigns but will not be able to challenge for a potential Europa League spot in the final weeks of this season unless there is a dramatic turn of events.
Wolves are not in any relegation trouble, sitting nine points clear of the bottom three, but they are six points off 10th-placed Aston Villa, and it is difficult to imagine them pushing into the top half of the division.
Nuno's team have only picked up two points from their last four Premier League matches, meanwhile, and suffered a 1-0 defeat to Liverpool in their last game before the international break.
Wolves have also found it difficult to show consistency at Molineux this term, winning just five of their 14 league games on home soil, and they lost 4-0 to West Ham in the reverse match at the London Stadium.
West Ham, meanwhile, will be eyeing fourth position in the table due to Chelsea's shock 5-2 home defeat to relegation-threatened West Bromwich Albion on Saturday afternoon.
The Hammers would drop down into seventh spot if both Liverpool and Tottenham Hotspur win on Saturday and Sunday respectively, but David Moyes's side will know that a victory at Molineux would move them onto 52 points and into the top four.
The London club will enter the contest off the back of a 3-3 draw with Arsenal on March 31; West Ham raced into a three-goal lead against the Gunners at the London Stadium but were ultimately made to settle for a share of the spoils courtesy of a fightback from the visitors.
Moyes's team lost their last away league match at Manchester United in the middle of March, meanwhile, and will know that they cannot afford many slip-ups in order to claim a top-four position.
The Hammers have been excellent at home this season, boasting the second-best record in the league, but they have dropped points in eight of their 14 matches on their travels.
Rui Patricio is available for Wolves on Monday despite the fact that the Portuguese goalkeeper was knocked out during his side's 1-0 loss to Liverpool before the international break.
Raul Jimenez continues to make strides forward as he recovers from a serious head injury, but the Mexico international will not be involved here, meaning that Willian Jose could start alongside Adama Traore and Pedro Neto as part of a front three.
It seems more likely that Fornals will make his return from the bench, though, with Moyes not prepared to take any risks when it comes to the Spaniard's long-term fitness.
Wolverhampton Wanderers possible starting lineup:
Patricio; Boly, Coady, Saiss; Semedo, Neves, Dendoncker, Jonny; Traore, Willian Jose, Neto
West Ham United possible starting lineup:
Fabianski; Coufal, Dawson, Diop, Cresswell; Rice, Soucek; Bowen, Lingard, Benrahma; Antonio
We say: Wolverhampton Wanderers 1-1 West Ham United
West Ham will be desperate to rise into the top four, but there is no question that this is a potentially very tricky match for the Hammers. It would not be a surprise to see the visitors collect all three points, but we can just sense a draw here, with Wolves more than capable of picking up a share of the spoils.
Watch the Sports Mole Football Shorts prediction for this game below: