In another defensive boost for the Hammers, Craig Dawson is back in contention after serving a suspension last weekend, so Balbuena could take his place on the bench as Dawson links up with Issa Diop and Angelo Ogbonna in a back three.
The veteran Mark Noble will likely line up alongside Tomas Soucek in the middle as Declan Rice recuperates from his knee injury, while Pablo Fornals will hope to feature further forward ahead of Said Benrahma and Manuel Lanzini.
Michail Antonio has not been ruled out of this contest by Moyes, but he would surely take his place on the bench if he passes a late fitness test, meaning that Jarrod Bowen and Jesse Lingard are set to continue up top.
There were initial concerns over Lingard's fitness earlier in the week, but the Manchester United loanee - whose goals have been worth 10 points to the Hammers since he joined - is expected to be fit for the trip to Lancashire.
West Ham possible starting lineup:
Fabianski; Dawson, Diop, Ogbonna; Coufal, Soucek, Noble, Fredericks; Fornals; Bowen, Lingard
Watch the Sports Mole Football Shorts prediction for this game below: