Ledley suffered an injury in his side's 2-0 Champions League qualifying win over Helsingborg last Tuesday, ruling him out of Wales's World Cup qualifiers.
Meanwhile, there is a return for West Ham United defender James Collins for the first time since March of last year.
Goalkeepers: Brown, Myhill, Price
Defenders: Blake, Collins, Gunter, Lynch, Matthews, Ricketts, Taylor, A Williams
Midfielders: Allen, Crofts, Edwards, King, Ramsey, J Williams, Bale
Forwards: Bellamy, Church, Morison, Robson-Kanu, Vokes