The Spanish outfit have picked up two wins from six league games to occupy 10th spot in La Liga. In their opening Champions League Group F match last month , they went down 2-1 to Bayern Munich.
Lille have not fared much better, securing just one win in Ligue 1 thus far this season. They have not picked up a single victory in their last five competitive matches.
Their 3-1 home defeat to BATE Borisov on matchday one was arguably the shock result of the competition thus far.
Valencia recorded a 3-1 victory the last time the pair clashed in the Europa League in 2009 and they have won each of their last seven home games against French opposition.
Valencia: Guaita; Pereira, Rami, Ruiz, Cissokho; Feghouli, Costa, Gago, Viera; Jonas, Soldado
Lille: Landreau; Beria, Basa, Chedjou, Digne; Mendes, Pedretti, Mavuba, Gueye, Payet; Roux
Sports Mole says: 2-1