Bolivia vs. Uruguay (Thursday, 10.00pm)
Heavily-fancied Uruguay have collected just one point from their opening two games, having drawn to Chile last time out, while their opponents sit at the foot of the group after consecutive defeats.
We say: Bolivia 0-2 Uruguay
Despite a disappointing start to the tournament, Uruguay should have more than enough to get past a struggling Bolivia side on Thursday.
This is a great opportunity for them to kickstart their tournament and book their place in the final eight, and they will aim to build confidence starting with a dominant performance in Cuiaba.
Chile vs. Paraguay (Friday, 1.00am)
Chile will look to confirm their place in the Copa America quarter-finals on Friday, when they take on Paraguay in their final game of the group stage.
Martin Lasarte's men currently sit second in the group, having collected five points from three games, while their opponents occupy third spot with three points from their two matches so far.
We say: Chile 2-0 Paraguay
Although Paraguay look an exciting prospect, Chile should have enough to pick up another three points on Friday, having shown their quality in the group stage.
The pairing of Maripan and Medel has been formidable so far, and they will aim for a clean sheet, while Lasarte's attack will have enough chances to take the game away from Paraguay.