The 44-year-old was appointed the manager of the national team in 2011 before penning fresh terms with the Irish Football Association at the start of the month.
However, O'Neill has managed just one win during his two-year spell as Ireland boss.
Turkey come into the match having recently finished in fourth place in their World Cup qualifying group.
Shane Ferguson did not travel with his teammates on Tuesday due to illness, but the midfielder is expected to be available for the match.
Turkey: Demirel; Gonul, Kaya, Toprak, Kaldirim; Adin, Topal, Inan, Turan; Bulut, Yilmaz
Ireland: Carroll; McGivern, Evans, Hughes, McPake; Davis, Baird, Ferguson, Steele; McKay, Paterson
Sports Mole says: 2-0