The 20-year-old joined Paul Clement's side on a season-long loan deal from Bayern Munich on deadline day, and comes straight into the middle of the park in just one change to the XI that started the victory at Crystal Palace last time out.
Defender Mike van der Hoorn is the man to make way as Clement shuffles his pack to accommodate Sanches's arrival, with Kyle Naughton dropping to the right of a back three that sees captain Federico Fernandez play in the middle and Alfie Mawson continue on the right.
Meanwhile, Wilfred Bony is forced to wait for his first start for the club following his deadline-day return from Manchester City and takes a place among the substitutes.
The visitors are without manager Rafael Benitez in person as he recovers from surgery, but calling the shots from afar, he makes two changes to the side that claimed their first victory of the season with a 3-0 win over West Ham United last time out.
Swansea City: Fabianski; Naughton, Fernandez, Mawson; Fer, Clucas, Sanches, Carroll, Olsson; Ayew, Abraham
Subs: Nordfeldt, Rangel, Van der Hoorn, Roque Mesa, Routledge, Narsingh, Bony
Newcastle United: Elliot; Manquillo, Lascelles, Clark, Gamez; Merino, Hayden; Ritchie, Perez, Murphy; Joselu
Subs: Woodman, Shelvey, Gayle, Diame, Lejeune, Yedlin, Atsu
Keep up with every twist and turn of the action from South Wales this afternoon with Sports Mole's live text commentary here.