The former Sevilla ace, who has 11 goals in 26 appearances in his first season in English football, misses out on the relegation six-pointer through injury.
Swans boss Paul Clement makes three changes in all from the side that lost 2-0 to Bournemouth prior to the international break, with Kyle Naughton, Martin Olsson and Luciano Narsingh all coming into the side.
Visitors Boro, who are winless in 11 and have lost five of their last seven, make just the one alteration from the 3-1 reverse to Manchester United a fortnight ago - Adama Traore coming in for Grant Leadbitter in midfield.
Swansea City: Fabianski, Naughton, Fernandez, Mawson, Olsson, Carroll, Fer, Cork, Narsingh, Sigurdsson, Ayew
Subs: Nordfeldt, Van der Hoorn, Kingsley, Ki, Montero, Borja, McBurnie
Middlesbrough: Valdes, Fabio, Bernardo, Gibson, Barragan, Clayton, Ramirez, De Roon, Traore, Downing, Negredo
Subs: Guzan, Ayala, Forshaw, Guedioura, Leadbitter, Stuani, Gestede
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