The competition - previously known as the Football League Trophy - had included 16 Under-21s sides from select Premier League and Championship outfits for the first time this season, in addition to all 48 teams from League One and Two.
In the third round of the competition, due to be played in the second week of January, League One leaders Scunthorpe United face a trip to Oxford United, while third-tier strugglers Chesterfield visit League Two Luton Town.
Draw in full:
Mansfield Town vs. Walsall or Oldham Athletic
Luton Town vs. Chesterfield
Oxford United vs. Scunthorpe United
Blackpool vs. Wycombe Wanderers
Cheltenham Town or Leicester City U21s vs. Bradford City
Yeovil Town vs. Southampton U21s or Reading U21s
Coventry City vs. Brighton & Hove Albion U21s
Swansea City U21s vs. Wolverhampton Wanderers U21s