Hosts Sunderland memorably reached the final of last year's competition, beating Chelsea and Manchester United along the way, before falling 3-1 to Manchester City in the final.
They are through to the third round of this year's competition after a comfortable victory over Birmingham last month.
That still remains the Black Cats' only win this season, though. They have drawn four and lost one in the league to lie 17th in the early table.
Visitors Stoke, meanwhile, aren't much better off in the league with five points from five games. They were moments away from victory on Saturday, but conceded a late equaliser at Queens Park Rangers.
The Potters reached the third round by seeing off Portsmouth.
These two sides are yet to play each other in the league this season, with Sunderland claiming a 1-0 victory in their last meeting in January.
Possible starting lineups
Sunderland: Pantilimon, Vergini, Brown, O'Shea, Van Aanholt; Buckley, Cattermole, Bridcutt, Gomez, Johnson; Altidore
Stoke: Sorenson; Muniesa, Huth, Wilson, Pieters; Whelan, Sidwell; Bojan, Arnautovic, Assaidi; Diouf
Sports Mole says: 3-2