Mainz recorded their own first home win of the season with a shock 3-2 victory over RB Leipzig last weekend, which moved them to within seven points of safety.
With just one win from their last seven matches, Stuttgart's dip in form has seen them cut adrift in the bottom half of the table.
It looked like being an entirely different afternoon when Silas Wamangituka fired the visitors into the lead with his 10th Bundesliga goal of the season after only seven minutes, but Freiburg responded twice before half time through Ermedin Demirovic's deflected effort and Jeong Woo-yeong's composed finish after sloppy defending by Pascal Stenzel.
Erik Thommy and Gonzalez both struck the post in the second half, but Matarazzo's side could not find a way back into the game despite having 27 shots and 60% possession across the 90 minutes. If they play as progressively once again, though, that elusive maiden home win could finally be discovered against struggling Mainz on Friday.
However, Mainz may have something to say about that after Saturday's surprising victory against Leipzig may provide them with a shot in the arm in terms of surviving relegation.
Bo Svensson looks to have provided his players with more belief having also gained an impressive point at Borussia Dortmund recently, but the 41-year-old will know there is a long way to go before his players can even contemplate safety.
There was an element of fortune about the win, too, with central defender Moussa Niakhate twice equalising from close range from set-pieces in the first half after Tyler Adams and Marcel Halstenberg had given the visitors the lead on two separate occasions after fine work by Marcel Sabitzer and Dayot Upamecano respectively.
Leandro Barreiro stunned the visitors with a deft near post finish after superb wing play by Danny da Costa to provide Mainz with a crucial three points, which still leaves Svensson's side five points off the relegation playoff position ahead of their trip to to Stuttgart.
Stuttgart Bundesliga form: LLWDLL
Stuttgart form (all competitions): WLWDLL
Mainz 05 Bundesliga form: LLLDLW
Mainz 05 form (all competitions): LLLDLW
Borna Sosa missed the trip to Freiburg with a muscle injury picked up in the defeat to Arminia Bielefeld, and is unlikely to return until mid-February.
Goalscoring hero Barreiro appeared to pick up a head injury in the win against Leipzig, so may sit out the trip to Stuttgart, too.
Stuttgart possible starting lineup:
Kobel; Mavropanos, Anton, Kempf; Coulibaly, Endo, Mangala, Wamangituka; Klimowicz, Castro; Gonzalez
Mainz 05 possible starting lineup:
Zentner; St Juste, Bell, Niakhate; Da Costa, Oztunali, Latza, Mwene; Stoger; Quaison, Onisiwo
We say: Stuttgart 2-1 Mainz 05
With Mainz missing Barreiro and Kohr, the visitors could prove a little lightweight in midfield against Stuttgart's lightning counter-attacks.
Whether Matarazzo's side get the opportunity to transition too frequently is another matter, but we can see them narrowly eking out a first home win of the season on Friday night.