Royals boss Brian McDermott can lead his side to six points clear of the relegation zone if they manage to clinch a victory on home turf.
Meanwhile, Stoke, who have suffered four victories in their last six matches, are in danger of dropping down two spots from 10th in the table if the teams below them are able to snatch maximum points over the weekend.
Possible starting lineups
Stoke: Begovic; Shotton, Shawcross, Huth, Wilkinson; Walters, Cameron, Nzonzi, Whelan, Etherington; Crouch
Reading: Federici; Kelly, Pearce, Mariappa, Harte; Kebe, Leigertwood, McAnuff, Le Fondre; Pogrebnyak, Akpan
Sports Mole says: 1-1