While the Potters are without a win in three matches, Blackburn's dramatic victory over Rotherham United in midweek was their first success in four attempts.
Blackburn have endured somewhat of a mixed campaign, combining having the best attacking record in the division for much of the season with inconsistent results.
However, their 97th-minute winner against Rotherham in midweek has the potential to act as the catalyst for an improved run during the Christmas period as they bid to improve on 11th spot.
The 17-year-old has contributed a goal or assist in four of his last five appearances, form which will not have gone unnoticed back at Anfield.
While Rovers are back to within four points of the playoffs, they can ill-afford another negative result against opponents who are rivals for a place in the top six.
With just three goals being scored in half a dozen fixtures, Stoke have done well to remain within a victory of reclaiming a place in the playoffs.
Regardless of the fact that they have kept five clean sheets in half a dozen outings, the Staffordshire outfit will not achieve promotion without considerable progress being made in the final third.
Stoke City Championship form: DWWLDD
Blackburn Rovers Championship form: WWDLLW
Fletcher will almost certainly return to the Stoke attack in a move which could see Brown move out to the right flank.
Jordan Thompson should also earn a recall in midfield, but O'Neill may limit himself to just two changes due to the extra day of recovery.
Having made two substitute appearances over the past week, Stewart Downing could be handed his first start in a Blackburn shirt.
Stoke City possible starting lineup:
Bursik; Collins, Souttar, Chester, Fox; Thompson, Cousins; Brown, Powell, McClean; Fletcher
Blackburn Rovers possible starting lineup:
Kaminski; Nyambe, Lenihan, Ayala, Bell; Downing, Johnson, Rothwell; Elliott, Armstrong, Gallagher
We say: Stoke City 1-2 Blackburn Rovers
With Stoke struggling to score goals, it heaps more pressure on their backline to keep out Armstrong and co. Although this will almost certainly be a competitive encounter, we expect the the extra firepower in the Rovers attack to prove decisive.