The England international has missed the Villans' last five games with a shin injury, but he returned to training earlier this week.
Speaking at his pre-match news conference on Friday, Smith revealed that he will make a decision on whether Grealish can play any part on the morning of the match.
Even if the playmaker is fit to feature, however, he will surely be eased back into action from the bench.
Ollie Watkins seems certain to lead the line, three days on from being called up to the England senior squad - a reward for scoring 10 goals in 27 league games this term.
Aston Villa possible starting lineup: Martinez; Cash, Konsa, Mings, Targett; Luiz, Nakamba; Traore, McGinn, Trezeguet; Watkins
Watch the Sports Mole Football Shorts prediction for this game below: