The Wales left-back has not featured since picking up the issue against Aston Villa in late March, with Spurs interim head coach Ryan Mason admitting that the defender is unlikely to feature again for his club this season.
Davies may instead be focusing on recovering in time to make Wales' Euro 2020 squad after playing an integral part in helping his nation astonishingly reach the semi-finals in 2016.
Otherwise, though, Mason appears to have a clean bill of health to select from against Wolves, with changes likely after a desperately disappointing performance during the 3-1 defeat at Leeds United last weekend.
Tanguy Ndombele and Lucas Moura have only been used from the substitutes' bench in recent weeks and could replace Dele Alli and Gareth Bale in order to provide greater industry in attacking midfield areas.
In defence, Matt Doherty will hope to receive a chance to impress against his former club, especially after Serge Aurier endured a torrid time against Jack Harrison and subsequently Raphinha after the Brazilian winger's second-half introduction in the encounter at Elland Road.
Eric Dier was also caught napping on several occasions against Marcelo Bielsa's side, with Davinson Sanchez potentially the beneficiary in terms of receiving a place at centre-back in Mason's first XI.
Tottenham possible starting lineup: Lloris; Doherty, Sanchez, Alderweireld, Reguilon; Lo Celso, Hojbjerg, Ndombele; Moura, Kane, Son
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