Both managers have plenty to ponder when it comes to team selection during a hectic first week of March, and with that in mind, Sports Mole rounds up the latest team news for the two London rivals.
Sports Mole's predicted XI: Areola; Tete, Andersen, Adarabioyo, Robinson; Reed, Lemina; Cavaleiro, Loftus-Cheek, Lookman; Maja
Out: Giovani Lo Celso (thigh)
Sports Mole's predicted XI: Lloris; Doherty, Dier, Sanchez, Reguilon; Hojbjerg, Sissoko; Bale, Moura, Son; Kane
Watch the Sports Mole Football Shorts prediction for this game below: