As for the travelling Magpies, safety is already achieved for Rafael Benitez's men, but the club will now be hoping to snap a problematic three-game losing streak as the season draws to a close.
Spurs head into the rearranged fixture off the back of a surprise 1-0 away defeat at West Bromwich Albion that has just opened the door a little more for top-four chasing Chelsea.
Pochettino's side still find themselves very much in the driving seat and while the Blues might be a concern over their collective shoulder, Spurs will still have bigger aspirations of moving above Liverpool into third place.
Up until recently Tottenham's league exploits have been outstanding, having lost just once in 18 top-flight matches, but the recent defeat to the Baggies has added further tension to a period that also saw the club outclassed by Manchester City and held by Brighton & Hove Albion.
Pochettino has already revealed his frustration after drawing to the Seagulls and losing to Darren Moore's charges, although the coach has since called on his players to move on quickly and focus on usurping Liverpool. Victory over Newcastle on Wednesday would move Spurs into third place, two points clear of the Reds with just one game left to play this term.
Spurs will be hoping to get back on track quickly as they aim to wrap up Champions League qualification. The loss at The Hawthorns over the weekend proved to be the first time in 24 Premier League contests that the Lillywhites were unable to score.
Harry Kane will likely be pipped to the Golden Boot by Mohamed Salah this term, but the England forward requires just one goal on Wednesday to draw level with George Hunt, who stands as the club's sixth-highest scorer with 138 goals.
Pochettino will be well aware of the club's successes against promoted sides ahead of the game. Spurs have won their last 17 home top-flight fixtures with promoted teams, and Tottenham will fancy their chances against an out-of-form Magpies side when they head into the first of two home games to end the campaign.
That said, Spurs will be coming up against an outfit that have often proven problematic for Tottenham; should Spurs win midweek it would be their first league double over the Magpies since the 2004-05 season.
Recent form: WWLDWL
Recent form (all competitions): WLDLWL
Miracle-working Benitez has arguably exceeded all expectations this season, keeping the Magpies up after promotion on nothing but a shoestring budget and unquestionable support from the Toon faithful.
Political implications off the field have left the Spanish coach restricted in the transfer market and it therefore cannot be overlooked what Benitez has achieved during his short stint at St James' Park: a promotion from the toughest second-tier division around at the first time of asking, followed by Premier League safety the very next term.
Following four straight Premier League wins to guarantee themselves safety, Newcastle have now lost three on the bounce and Benitez will be keen to ensure that the Magpies get something from their final two games in order to position himself strongly ahead of what could be a politically-argumentative summer for the coach and the club's board.
The Magpies were poor during the first half in their recent 2-1 defeat at Watford, but some impressive tactical changes from Benitez almost saw the visitors get back into the game in a second-half showing that will likely give Newcastle momentum heading to Wembley Stadium.
Away fixtures with Spurs have proven freakishly profitable for Newcastle in recent years too - as things stand, Newcastle have won their last three Premier League trips to Tottenham.
Added to that, the Magpies have bounced back to win from losing positions on six different occasions in Premier League history. No other side has as many comeback wins against one particular opponent in the annals of the division.
Ayoze Perez will be itching to get back onto the pitch as he finds himself in an impressive purple patch of late. The frontman now has four goals in his last six league showings, and has also scored the winner in Newcastle's last two away victories over Spurs.
With little but pride and Benitez's appearance to play for, Newcastle will be having to turn the tide on some problematic club form against top-four sides to beat Spurs. The Magpies have recorded just one win in 50 Premier League away matches against teams beginning the day in the division's top-four positions.
Recent form: WWWLLL
Perez enjoys scoring against Spurs, and the forward is likely to play in the hole just behind lone frontman Dwight Gayle for the trip south this week.
Tottenham Hotspur possible starting lineup:
Lloris; Trippier, Sanchez, Vertonghen, Davies; Wanyama, Sissoko; Eriksen, Alli, Moura; Kane
Newcastle United possible starting lineup:
Dubravka; Yedlin, Lascelles, Lejeune, Dummett; Ritchie, Diame, Shelvey, Kenedy; Perez; Gayle
Head To Head
Spurs won the corresponding fixture earlier in the season at St James' Park courtesy of a 2-0 victory, Alli and Davies scoring to defeat 10-man Newcastle.
The clubs have played each other 45 times in the history of the league, Newcastle winning 21 to Tottenham's 18. The Magpies have nine away victories over Spurs.
Tottenham's last home league win against Newcastle came at the old White Hart Lane in 2013, when a rising Gareth Bale netted a brace in a 2-0 victory in London.
We say: Tottenham Hotspur 3-1 Newcastle United
Events in the top four have left Spurs sweating on a Champions League place, but a victory at home would lift them into third and put them on the verge of wrapping up European qualification on the final day of the season this coming weekend.
Pochettino's side have looked a little lacklustre going forward in recent weeks, and the Argentine coach will be hoping that Chelsea's resurgence will now focus his team fully on securing a top-four finish.
As for the Magpies, onlookers would be forgiven for thinking that this Newcastle side have been on the beach for the last few weeks. Benitez will be pushing his players to prove people wrong by finishing strongly in what has undoubtedly been a remarkable season for the players, staff and fans at the club.