Hull City manager Steve Bruce is expected to make alterations after seeing his side suffer back-to-back defeats to Southampton and Burnley.
Those setbacks have seen the Tigers drop to 15th position in the league table, just two points above the relegation zone.
Former Tottenham Hotspur defender Michael Dawson should be fit to face his former side, while goalkeeper Allan McGregor is likely to replace Steve Harper.
There could also be a change in attack, with Nikica Jelavic ready to start alongside Abel Hernandez instead of Sone Aluko.
Spurs boss Mauricio Pochettino revealed at his pre-match press conference that several players were injury concerns ahead of the trip to the KC Stadium.
Pochettino refused to name which players, but Andros Townsend could be absent after being forced to withdraw from England duty.
Spurs, who have suffered defeats in three of their last four Premier League fixtures, will also be without Kyle Naughton through suspension.
Hull City:
Recent form: LWDDLL
Possible starting lineup: McGregor; Davies, Dawson, Chester, Elmohamady; Brady, Huddlestone, Livermore, Diame; Jelavic, Hernandez
Tottenham Hotspur:
Form in Premier League: DWLLWL
Form in all competitions: WLWWWL
Possible starting lineup: Lloris; Dier, Vertonghen, Kaboul, Rose; Capoue, Mason; Chadli, Eriksen, Lamela; Kane
Sports Mole says: 1-2
Darren Plant
