City have not lost a league game at home in over a year, but Vertonghen believes that Spurs' away form is good enough to end that record.
The 25-year-old also believes that now is a good time to play Roberto Mancini's men, who have won just one of their last four games in all competitions.
"City have been struggling a bit with their confidence and we are strong in away games. We can hurt them on the break," the Belgian said.
"We want to win there and we're capable of it. Why not? City are one of the best teams in the Premier League but with our pace we can hurt anybody, so we're hopeful of getting a good result."
Spurs currently sit sixth in the Premier League table, three places and five points behind City.