The Hammers visited White Hart Lane in dismal form, having not won since the opening day of the season, but produced a stunning second-half display to run-out 3-0 winners.
Tomkins, who described the atmosphere as unforgettable, believes that there is a new-found confidence at the club since the victory.
"It's amazing what a win can do! Ever since, everyone's come in buzzing from what happened at the weekend," he told the club's official website.
"It's certainly an atmosphere that I won't ever forget in my career. A 3-0 win at White Hart Lane, it doesn't get much better than that.
"We always stay positive at the Club and we knew it was a massive game for the fans and everyone involved. It was a massive victory. I'm still pinching myself that we've beaten Tottenham 3-0 at White Hart Lane."
The win moved Sam Allardyce's side out of the bottom three and up to 13th in the Premier League.