The Portuguese cited playmakers Gylfi Sigurdsson and Lewis Holtby as the two most likely to fill the void left by Bale, who came off on a stretcher in Thursday's Europa League match against Basel and will be out for a couple of weeks.
"We have suffered setbacks before and managed to jump out of them so let's wait and see," said Villas-Boas ahead of today's visit of Everton in the Premier League.
"We've had [Bale's] absence before in different moments of the season and we had people stepping up to the game. When an injury happens to a player who has played most of the time it allows another player to step in.
"We have those players - Sigurdsson has gone back to his goalscoring form, scoring two during the internationals and once against Basel, and Holtby was also at a very, very good level."
Spurs could strengthen their grip on third place in the table if they triumph and Chelsea slip up against Sunderland.