Find out how all of the action unfolded courtesy of our minute-by-minute updates below.
There is no love lost between these two sides, and that feeling will have only been strengthened after the Hammers effectively ended Tottenham's title hopes last season. The visitors will be looking for revenge today, but they come up against a West Ham side who have improved of late.
Before we take a more in-depth look into that, though, let's first check out the team news...
Well, the headline news as far as the home side are concerned is that there is no Andy Carroll in the side today, despite West Ham's improved form since his return. Carroll has played two Premier League games this season and West Ham have taken four points from that time, compared to zero from the three matches they have been without the big striker.
The Hammers had also averaged more than twice as many crosses during those two games, so the personnel change is likely to see a switch of style too today.
Hernandez had just one touch inside the area at The Hawthorns, which is where the Mexican really comes alive, so it is perhaps not surprising that Bilic has looked for a solution to get Hernandez involved in the game more today. One thing is for sure - if he gets a chance today, he is more than capable of putting it away.
Marko Arnautovic is the man who replaces Carroll in the side, with the former Stoke forward more than capable of creating chances for Hernandez or getting his own name on the scoresheet, while Michail Antonio, who also starts in that front three, has also developed a keen eye for goal during his time at the club.
Ogbonna and the fit-again captain Noble return to the side, but there is no place for Manuel Lanzini, who scored the only goal of last season's meeting here. Indeed, nine of Lanzini's 14 Premier League goals have come in London derbies - including three in four against Spurs - so the hosts could miss him today.
The England international has scored 19 goals in his 28 Premier League London derbies, and of the players to have played more than 10 of them in the Premier League, only Thierry Henry has a better goals-per-minute ratio. Against West Ham alone, Kane has scored five goals in his last five league games.
Only Lionel Messi, Edinson Cavani and Robert Lewandowski have scored more league goals in 2017 than Kane's 23, a tally he has reached in just 22 games. Kane has also scored an incredible nine goals in his last four Premier League away games.
In Eriksen, Spurs also boast a master provider, with no pairing in the Premier League creating more goalscoring chances for each other than the Dane and Kane.
It is one of two changes for Spurs from their goalless draw with Swansea last time out, and the other comes on the opposite flank as Davies returns after an ankle injury to replace Son. Sissoko, interestingly, retains his place in central midfield.
The Hammers do always seem to up their game against Spurs - this is their biggest game of the Premier League season, after all, but the way both sides have started the campaign, you'd still have to make Tottenham slight favourites to come away with all three points in this one.
Bilic was rumoured to be one game away from the sack at one stage this season, but victory over Huddersfield and a draw with West Brom seem to have bought the Croatian a bit more time to turn things around now.
As things stand, West Ham are 17th in the Premier League table, only out of the relegation zone on goal difference, and should they lose by three goals at the hands of Spurs here they will drop below the dreaded dotted line.
Of course, victory over Spurs would make things look a lot more rosy for Bilic, lifting West Ham up to 13th for a few hours at least.
Another shutout of Kane and co today would see the Hammers make it three in a row in the top flight for the first time since April - a run which culminated with a 1-0 win over Spurs, incidentally - and four in a row across all competitions for the first time since February 2014.
The Hammers are today bidding to win their opening two Premier League home games for the first time since 2012-13, and three consecutive matches at the London Stadium in all competitions for the first time ever.
That is one of three times Slaven Bilic has overseen a home match against a team managed by Mauricio Pochettino, and each time the Croat has come out on top by a 1-0 scoreline - twice with West Ham and once with Besiktas in the 2014-15 Europa League.
Spurs are still looking for their first three-point haul in the Premier League at their temporary home, most recently being held to a goalless draw there by Swansea City last weekend. As a result, they now sit five points adrift of the Manchester clubs.
Pochettino's side have won both of their league matches on their travels without conceding a goal, beating Newcastle 2-0 and Everton 3-0, the latter of which would have been a particularly pleasing result and performance for the North Londoners.
Having also conceded just two times during that run, Tottenham's four-match winning streak has seen them chalk up a goal difference of +16, which is the best over a four-game streak away from home in the top flight since way back in 1892.
This stadium, and Upton Park before it, has not been the happiest of hunting grounds for Tottenham over the years, though, and West Ham will be determined to keep that up today.
Pochettino will know that an eight-point gap is a sizeable one to make up, even at this early stage of the season, so it is important his side come away from this match with something.
Another defeat for Pochettino's side this afternoon would mark the first time that they have lost three top-flight London derbies on the bounce since August 2005, more than 12 years ago.
Having made a dream start to their campaign with victory over Borussia Dortmund on matchday one, Spurs next take on APOEL away in midweek, with the Cypriots expected to be the whipping boys in a group which also includes Real Madrid. It is still an away Champions League trip for Spurs, though, so if Pochettino gets the chance to rest any of his big guns today, he may well take it.
The Hammers relish these matches - the atmosphere is always intense and the players raise their game to face their biggest Premier League rivals. Spurs have the superior quality in their side, though, and are on fire away from home at the moment. It is likely to be a closer one than Tottenham have been used to in their recent matches on the road, but I am still backing the visitors to come out on top.
Sports Mole says: West Ham 1-2 Tottenham
The most recent of those came in May, when Manuel Lanzini scored the only goal of the game to effectively hammer the final nail into Tottenham's Premier League title hopes.
The Hammers have beaten Spurs 14 times in the Premier League, which is their highest tally of victories against any single opponent in the division.
The Hammers were on course for a 2-1 victory on their final ever visit to the Lane, leading in the 89th minute, but Kane levelled things up before adding a winner from the spot just two minutes later to complete a dramatic turnaround.
WEST HAM STARTING XI: Hart; Fonte, Reid, Ogbonna; Zabaleta Kouyaté, Noble, Cresswell; Antonio, Hernández, Arnautovic
TOTTENHAM STARTING XI: Lloris; Aurier, Alderweireld, Sanchez, Vertonghen, Davies; Dier, Sissoko, Eriksen, Dele; Kane
West Ham immediately break and Arnautovic does brilliantly to power between two Tottenham defenders on his way into the box, but Aurier recovers with a brilliant last-ditch saving challenge.
The England striker misses a sitter from just a couple of yards out following Aurier's powerful low cross into the box, but it wouldn't have counted anyway as he was offside.
Kane gets his first goal away to West Ham as the front three combine, with Eriksen sliding a pass through to Alli, who in turn provided the cross for Kane. The striker still has work to do, but he plants his header into the bottom corner past a helpless Hart.
Eriksen flicks the ball into the path of an adventurous Vertonghen, who in turn slides it down the channel for Alli. Hart comes out to thwart the midfielder's effort with a decent stop, but the ball rebounds straight to Kane, who is left with the easiest of finishes.
For West Ham, this one will be tough to take as they had been on top before those two Kane goals.
It is a slightly deceiving scoreline as West Ham were the better team for the majority of the half, but two goals in three minutes have seen Spurs take control.
Kane still had a lot to do, but his header slammed into the bottom corner to leave Hart helpless.
Again it was Kane to applied the finishing touch, rolling the ball into an empty net after Alli's effort had been saved by Hart and rebounded to the striker.
The hosts have had a bit of joy down the left flank, but even that avenue waned as the half wore on and they will need a significant improvement if they are to get back into this match in the second half.
It is so nearly a hat-trick for Harry Kane as his free kick from out on the left flank beats Hart and crashes against the foot of the post, but Spurs recycle the ball and feed it back into the area. Eriksen is there to get on the end of it, and he steers a controlled half-volley into the bottom corner.
Hernandez scores a typical poacher's effort to pull a goal back for his side, nodding in from close range after Fonte had flicked the initial corner on. There is still a lot to do for the hosts, but that at least gives them a bit of hope heading into the final 25 minutes.
The full-back sees his first Premier League start come to a premature end with a second yellow card in the space of six minutes as he launches himself into challenge from behind on Carroll. It is a needless challenge in a nothing area of the pitch, but Aurier made it anyway and Michael Oliver has little choice but to produce the red card.
This one is not over yet, folks!
It is a thumping header from Kouyate as he powers his finish past Llorente having got on the end of a sumptuous delivery on the run from Masuaku.
That is all we have time for this afternoon, but I will leave you with our match report and be sure to head over to the 3pm kickoffs for more live coverage!