The Lilywhites' focus may be elsewhere, though, with the first leg of their Champions League semi-final against Ajax coming three days after United's trip to the Tottenham Hotspur Stadium.
Ahead of this weekend's clash in North London, Sports Mole look at how Tottenham could line up.
Mauricio Pochettino must decide whether to rotate his squad before the Ajax clash or keep changes to a minimum.
Tottenham remain without a trio of players as Sissoko has joined Aurier and top scorer Kane on the sidelines.
Lamela and Winks are also fitness doubts and will have to be assessed ahead of Saturday's early kickoff.
With Son Heung-min ruled out of next week's first leg through suspension, the South Korean forward is almost certain to start on Saturday.
Danny Rose and Victor Wanyama could be given a breather, however, with Ben Davies an adequate stand-in at left-back and Eric Dier back in contention to take over from Wanyama, who played nearly 90 minutes of the 1-0 win against Brighton & Hove Albion in midweek.