Spurs saw out the final Premier League match before Christmas with a thumping 6-2 win away to Everton, meaning that they have now lost just one of their last 13 outings across all competitions.
Here, Sports Mole looks at how they could line up for Wednesday's match.
Pochettino has favoured a 4-4-2 diamond in his last two matches, and while he could be missing two key components of that in Dele Alli and Moussa Sissoko for this one, the success of the formation could see him stick with it.
Sissoko picked up a knock against Everton and has been used heavily recently, whereas Alli was taken off at half time at Goodison Park and may not be risked, despite his hamstring problem only being a minor one.
Rotation is an option for Tottenham, but the manner of their victory on Sunday could mean that Pochettino avoids making many changes, with two-goal duo Harry Kane and Son Heung-min continuing to lead the line.
There are fewer options at the back for Spurs, although Danny Rose could give Ben Davies a rest and Kyle Walker-Peters is available on the opposite flank should Kieran Trippier suffer any signs of fatigue.