Here, Sports Mole looks at the England international's record against this weekend's opponents in previous matches.
Kane has faced City on six previous occasions, with each of those matches coming in the top flight. The first of those was in the 2012-13 season when on loan with Norwich City, finding himself on the wrong end of a 4-3 defeat at Carrow Road.
The 24-year-old was not part of the Spurs squad for the following season's matches, both of which ended in heavy defeats for his side, but he has played a part in five of the last six top-flight encounters.
Just two of those matches have yielded a goal, as he found a way through in 4-1 and 2-1 victories for his side two seasons ago.
Blanks have been fired in his last two meetings with City, though, and he was fortunate not to be shown a straight red card for a bad challenge Raheem Sterling in December's clash.