Spurs moved into Wembley at the start of the season as their new 62,000-capacity stadium at White Hart Lane was being built.
Mauricio Pochettino's side struggled in the opening stages of the campaign at their temporary home but have not lost at the showpiece stadium in the Premier League since August.
Spurs cruised into the last four of the FA Cup for the second successive season by winning 3-0 at Swansea City on Saturday, and Vertonghen is looking ahead to playing in now-familiar surroundings.
"It definitely helps us because we have played well there," Vertonghen told the Evening Standard.
"We've beaten some big teams there and had some very good games, apart from the start of the season when it was a bit difficult for us.
"Juventus (who knocked Spurs out of the Champions League) wasn't great, but Wembley suits us and we've had a good season there. We really feel at home there.
"At the beginning of the season everyone was talking about [the poor form] - after the Chelsea, Burnley and West Brom games. There were a couple of games which we should have won and we didn't.
"But after the Champions League games things turned around and we felt we could beat everyone there. I like playing at Wembley now."
Spurs are seeking to win their first trophy since 2008, when they lifted the EFL Cup.