The club's top goalscorer faces at least a month on the sidelines after sustaining ankle ligament damage in the 4-1 victory over Bournemouth last weekend.
However, Pochettino has acknowledged that he is happy with the club's strength in depth in the final third, and admits that he has a number of options to choose from ahead of Saturday's FA Cup quarter-final tie at Swansea City.
"For me most important is how you are going to use the same in every single game, trying to defeat the different tactics that the opponent is going to use. But I think we have quality enough and different alternatives we can use. Now I need to be right, picking what is going to be the best for every single game when Harry is out."
Pochettino has admitted that he is placing extra focus on the FA Cup after the club's exit from the Champions League.