Enrique controversially left Sergio Ramos out of his squad for this summer's competition, and it is going to be fascinating to see how La Roja line up for their first Group E fixture.
Robert Sanchez is one of two uncapped players in the Euro 2020 squad, but it has been widely reported that the 23-year-old will be given the nod between the sticks for this match.
The other two positions in the final third are certainly open, but Ferran Torres has become an important player under Enrique and should therefore feature, while Mikel Oyarzabal may get the nod on the opposite side.
This match provides an opportunity to have a look at a number of different things ahead of Euro 2020, and there should be a first cap for Aymeric Laporte, who has declared for Spain over France.
Spain possible starting lineup: Sanchez; M Llorente, Garcia, P Torres, Alba; Koke, Busquets, Pedri; F Torres, Moreno, Oyarzabal