Southampton have little to play for in the closing stages as they lie 12th in the table, whereas Brighton occupy 15th spot - five points clear of the relegation zone.
Travelling to Old Trafford to face a free-scoring Manchester United side would not have filled the Southampton faithful with confidence on Monday, but the Saints managed to end United's winning run to salvage a point in a four-goal thriller.
Stuart Armstrong's opener was quickly cancelled out by strikes from Anthony Martial and Marcus Rashford, and Southampton's unbeaten run seemed destined to come to an end before Michael Obafemi bundled in an equaliser deep into injury time.
The result means that Ralph Hasenhuttl's men continue their strong run of form and have now taken eight points from their last 12 on offer, and Saints fans can certainly feel optimistic heading into next season given the manner of their side's recent performances.
Since the Premier League was given the green light to resume, Southampton have only suffered one defeat from six in the English top flight, and Hasenhuttl's side can rest easy knowing that they have secured yet another season of Premier League football.
The Saints will no doubt want to make a statement of intent heading into next season, though, with fixtures against Bournemouth and Sheffield United to follow before Hasenhuttl can begin making preparations for the 2020-21 campaign.
Brighton have been handed one of the toughest fixture lists upon the Premier League's restart, and the Seagulls felt the full force of a Manchester City onslaught at the weekend.
Following on from their home defeat to champions Liverpool, Brighton had little time to dwell on that defeat as they welcomed last season's champions to the South Coast just a few days later, and the Citizens went about their business comfortably as a Raheem Sterling hat-trick helped City record a 5-0 drubbing over Brighton.
Despite having tasted defeat in three of their last four Premier League outings, Graham Potter's men should have done enough to ensure survival with just three games left to go, although they will need to be wary of four out of five sides below them picking up wins last time out.
The battle to avoid relegation is, as per usual, expected to go right down to the wire, and Brighton will be determined to pick up as many points as possible in their remaining fixtures with Southampton, Newcastle United and Burnley as the 2019-20 season draws to a close.
Brighton have not beaten the Saints since the two clubs were plying their trade in the Championship, however, with Southampton recording wins in the last two meetings between the South Coast clubs.
Southampton Premier League form: WLWWDD
Brighton Premier League form: WDLWLL
The hero of the hour at Old Trafford, Michael Obafemi, will certainly be hoping that his contribution on Monday is rewarded with a spot in the starting lineup for the midweek showdown with Brighton.
Southampton possible starting lineup:
McCarthy; Walker-Peters, Stephens, Bednarek, Bertrand; Armstrong, Ward-Prowse, Smallbone, Redmond; Long, Ings
Brighton possible starting lineup:
Ryan; Lamptey, Dunk, Webster, Burn; Stephens, Propper, Bissouma; Mooy, Maupay, Trossard
We say: Southampton 2-1 Brighton
Southampton have done themselves proud over the past few weeks with memorable results against the two Manchester clubs. The Saints boast a strong recent record over their South Coast rivals too, so we expect Hasenhuttl's men to keep their impressive run going with a narrow victory on Thursday evening.