Since this article was published, this match has been postponed due to the death of Queen Elizabeth II.
Brentford will aim to keep the momentum going from their pulsating seven-goal success over Leeds United when they travel to Southampton for Saturday's Premier League contest at St Mary's.
Thomas Frank's men ran out 5-2 winners over the Whites last time out, while the Saints fell to a 1-0 defeat away to Wolverhampton Wanderers.
Match preview
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Even with Raul Jimenez pulling up with an issue before kickoff and new signing Sasa Kalajdzic suffering an ACL injury less than an hour into his debut, a Wolves side boasting the league's least successful attack still found a way past Southampton last weekend.
Daniel Podence's goal just before half time condemned Ralph Hasenhuttl's side to defeat at Molineux and send them crashing back down to earth following their midweek success over Chelsea, but the Saints have not suffered the abysmal start to the season that some predicted.
Taking seven points from the first 18 on offer in the top flight means that Southampton occupy 12th spot in the table ahead of the visit of Brentford, but they are still waiting for their first clean sheet of the league season and have now conceded in each of their last 12 top-flight matches.
The late acquisition of Duje Caleta-Car and strong form of Armel Bella-Kotchap should certainly help the hosts obtain a long-awaited shut-out soon, but Hasenhuttl's side have responded very well when conceding first - as they have done in each of their last five Premier League games.
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Boldly claiming that Ivan Toney only sits behind Harry Kane in the list of England's top strikers, Brentford boss Thomas Frank could not stop singing the praises of the 26-year-old following his wonderful hat-trick in the 5-2 thumping of Leeds.
After ensuring that the match ball would belong under his arm with a penalty, a stunning free kick and a delicate chip some 20 yards from goal, Toney took a back seat as Bryan Mbeumo and Yoane Wissa completed the job for Brentford, who were not phased by Luis Sinisterra and Marc Roca's responses.
Brentford's defence has been far from impenetrable so far this term, but a continued emphasis on attacking stardom has elevated the Bees to eighth in the table at this early stage, and only Manchester City (20) can better their 15-goal haul so far.
Frank's side have now gone unbeaten in their last three Premier League matches and have lost just one so far this term - firmly cementing their place among the big boys - and picking up a first away win of the campaign is next on the agenda for the Bees.
All three of Brentford's away games in the top flight so far this term have seen both teams score, but the Bees were taught a footballing lesson in a 4-1 loss to Southampton at St Mary's last term before gleaning a slice of revenge with a 3-0 home win four months ago.
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Team News
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Southampton youngsters Romeo Lavia and Valentino Livramento remain out of contention through injury, and Caleta-Car needed more time to get up to speed following his deadline-day arrival so was not involved in the defeat to Wolves.
The Croatian centre-back will expect to be a part of the squad for this game, but Bella-Kotchap and Mohammed Salisu will expect to retain their partnership in front of Gavin Bazunu for the time being.
Nineteen-year-old Samuel Edozie caught the eye with his showing off the bench for Southampton at Wolves, but Stuart Armstrong and Ainsley Maitland-Niles are more likely to start if Hasenhuttl opts for an engine room change or two.
Brentford's situation on the injury front is almost identical, as Frank is set to be working without Christian Norgaard (Achilles) and Ethan Pinnock (knee) for the trip down south.
It remains to be seen if Sergi Canos will be able to battle back from a thigh injury in time to make himself available, but Aaron Hickey and Bryan Mbeumo's spots should be safe either way.
Competition is rife on the opposite flank as Wissa, Mikkel Damsgaard and Keane Lewis-Potter vie for chances to start, but the former's goal off the bench against Leeds could see him force his way back into the XI.
Southampton possible starting lineup:
Bazunu; Walker-Peters, Bella-Kotchap, Salisu, Perraud; Ward-Prowse, Diallo, Armstrong; Aribo, Armstrong, Djenepo
Brentford possible starting lineup:
Raya; Hickey, Jansson, Mee, Henry; Jensen, Janelt, Dasilva; Mbeumo, Toney, Wissa
We say: Southampton 1-2 Brentford
Southampton have developed into a force to be reckoned with when going behind, but Brentford are just as strong at responding to setbacks, which should lead to an entertaining battle with plenty of goalmouth action.
Frank's side have not been able to replicate their home successes on the road yet, but with Southampton not boasting a penchant for clean sheets, we can envisage the Bees running out narrow winners.
For data analysis of the most likely results, scorelines and more for this match please click here.
Top tip
Ben Knapton
