Meanwhile, Sunderland's strikers found form to fire them to their first top-flight win of the season as Steven Fletcher scored a double to down Stoke City, after Connor Wickham's fourth-minute opener.
Black Cats boss Gus Poyet has admitted that the victory has put a new spin on their start to the campaign, pointing out that they have now only lost one of their opening seven matches on their way to 13th spot.
Southampton's rapid adaptation to life under Ronald Koeman has surprised many who had tipped the South Coast club to struggle following the departure of five of their most important players over the summer.
However, Koeman has moved to assure Saints fans this week that he will not be leaving them to manage the Netherlands, should his country axe Guus Hiddink and come calling as some reports have suggested.
The defender, who signed a new contract at the Stadium of Light this week to boot, may not be partnered by former Manchester United teammate Wes Brown at St Mary's Stadium, with Poyet likely to persist with the O'Shea and Santiago Vergini combination which started against the Potters a fortnight ago.
That means that Billy Jones should continue at right-back in a visiting lineup showing just one change - the more physical and industrious presence of Jack Rodwell in midfield in place of the silky Jordi Gomez.
Graziano Pelle, who scored his first Italy goal to earn them a narrow win in Malta, will continue to lead the Saints line and could be supported by Shane Long, if Sadio Mane's travelling to and from Africa is taken into consideration.
Sunderland are unbeaten in eight games against Southampton, who themselves have not lost in five home matches.
Possible starting lineups
Southampton: Forster; Clyne, Fonte, Alderweireld, Bertrand; Wanyama, Davis, Schneiderlin; Tadic, Long, Pelle
Sunderland: Mannone; Jones, O'Shea, Vergini, Van Aanholt; Larsson, Cattermole, Rodwell; Buckley, Fletcher, Wickham
Sports Mole says: 1-0