The Owls go into the match hovering over the relegation zone as one of four teams on five points, although they have a game in hand on those below them.
Ipswich have been in reasonably good form of late, and head into the match in 10th place, with three points at Hillsborough potentially taking them up to eighth.
Both side's drew their last outings, with Keith Andrews's 89th-minute equaliser denying Wednesday an impressive victory at Brighton & Hove Albion, and Ipswich involved in a 4-4 thriller with Derby County.
Sheff Wed: DDDWLD
Possible starting lineups
Sheff Wed: Kirkland; Llera, Roger Johnson, Reda Johnson, Palmer; Johnson, McPhail, Coke, Antonio, Helan; Fryatt
Ipswich: Gerken; Chambers, Berra, Smith, Cresswell; Anderson, Skuse, Hyam, Tunnicliffe; Murphy, McGoldrick
Sports Mole says: 1-2