The former Chelsea man lasted just seven minutes into his return from injury during the 3-0 loss to Watford on Saturday that extended their winless run to five games.
Brentford go into the fixture on the back of a 0-0 draw away at Wigan Athletic as they recorded just their third clean sheet of the season.
That made it seven points from 12 for the Bees who have, so far, coped with their first appearance in the second tier of English football for over 20 years.
Boss Mark Warburton, who has seen his team win their last two home contests, could name an unchanged starting lineup.
Sheffield Wednesday: WLLDDL
Possible starting lineups
Brentford: Button, McCormack, Tarkowski, Craig, Bidwell, Douglas, Odubajo, Judge, Pritchard, Peleteiro Ramallo, Gray
Sheffield Wednesday: Westwood, Palmer, Lees, Loovens, Mattock, Drenthe, Lee, Semedo, Maghoma, Madine, May
Sports Mole says: 2-1