However, it was the home side who took an 18th-minute lead through Fryatt. The striker, who is on loan from Premier League side Hull City, was left with a simple finish after Antonio pounced on uncertainty in the Reading defence to square the ball to the 27-year-old.
The lead was doubled seven minutes later as Antonio cut inside from the right wing and sent a shot underneath the body of Alex McCarthy to make it 2-0 to the Owls.
However, Reading grabbed a goal back 10 minutes before the break through Pavel Pogrebnyak's header from Chris Gunter's cross.
The two-goal cushion was restored three minutes before half time when McCarthy's save from a Connnor Wickham shot rebounded into the net off the prone Morrison.