A record of two wins and four defeats from six matches this season has seen Athletic collect six points, leaving them in 16th position in the table, just one point outside of the relegation zone.
Gaizka Garitano's side picked up an important win at home to Levante on October 18, but they have lost three of their last four in the league, including a 1-0 defeat at Osasuna last weekend.
Worryingly, Athletic have not scored a single goal in their last three defeats, and it could well be a difficult campaign for the club, who finished 11th in Spain's top flight last season.
The eight-time La Liga champions have lost two of their last three league games with Sevilla, meanwhile, including a 2-1 defeat in the corresponding match last term.
Sevilla, meanwhile, are going well in the Champions League this season, following a goalless draw with Chelsea by beating Rennes on Wednesday night to move onto four points in their section.
The Europa League winners have now lost their last two in the league, though, suffering a 1-0 defeat at Granada on October 17 before Eibar recorded a surprise 1-0 success at the Estadio Ramon last weekend.
A record of two wins, one draw and two defeats from five matches has left Sevilla in 13th spot in the table, although they do have two games in hand over a lot of the teams around them.
The matches are coming thick and fast for Lopetegui's side at the moment as they are back in Champions League action at home to Krasnodar on November 4 before hosting Osasuna in the league on November 7.
It would be fair to say that Sevilla are yet to seriously ignite their league campaign, but Los Nervionenses will be determined to collect all three points this weekend.
Athletic Bilbao La Liga form: LWLLWL
Sevilla La Liga form: WWDLL
Sevilla form (all competitions): WDLDLW
As mentioned, Williams, Muniain and Raul Garcia have struggled for goals this season, but the trio should continue in the final third of the field, while Alex Berenguer is expected to retain his spot.
As for Sevilla, Lopetegui is expected to make changes from the side that overcame Rennes in the Champions League on Wednesday night.
Franco Vazquez is also pushing for a place in the final third of the field, although Lucas Ocampos and Luuk de Jong should both keep their positions in attack. Jules Kounde is also available after recovering from coronavirus, while Joan Jordan served a one-game domestic suspension against Eibar and will return.
Athletic Bilbao possible starting lineup:
Simon; Capa, Yeray, Martinez, Yuri; D Garcia, Lopez; Muniain, R Garcia, Berenguer; Williams
Sevilla possible starting lineup:
Bounou; Navas, Kounde, Carlos, Acuna; Gudelj, Rakitic, Jordan; Ocampos, L de Jong, Munir
We say: Athletic Bilbao 1-2 Sevilla
Sevilla will be desperate to return to winning ways in La Liga, and we can see Lopetegui's side triumphing this weekend. Athletic have so much talent, but the Basque outfit have struggled for form this season, and we are expecting Garitano's side to suffer another disappointing result here.