Craig Levein's side travel to Brussels having taken just two points from their opening three games in Group A.
Meanwhile, Belgium are top of the table with seven points following an impressive 3-0 victory over Serbia on Friday.
Despite the differing form of the two teams, Vermaelen believes that Scotland will provide a stern test.
"It's not going to be easy because they have some good players who play in the Premier League," he told Sky Sports News. "They have a lot of experience.
"We got a massive three points on Friday and we want three points on Tuesday as well."
Vermaelen has been capped 39 times at senior international level.