Manchester United midfielder Darren will captain Craig Levein's side against Wales at the Millenium Stadium after missing 11 months of action with a chronic bowel illness.
The 28-year-old returned to domestic action for the Red Devils in September and is now poised to make his first Scotland appearance since November 2011.
Meanwhile, Sunderland striker Steven returned to the international fold after resolving his differences with Levein, who had previously refused to select him after he pulled out of a squad via text message.
Despite Levein claiming that Fletcher would not be guaranteed a place in the starting XI, the Scotland boss has named the in-form forward in his lineup for the clash in Cardiff, according to Sky Sports News.
The former Wolverhampton Wanderers star has scored five goals in as many Premier League appearances since joining the Black Cats in a record £14m move.