The Tartan Army are unbeaten in each of their last four matches across all competitions, while the Red Lions have won one of their last eight games on home soil.
Scotland began their preparations for their first major tournament since 1998 in positive fashion, after securing an impressive 2-2 draw against the Netherlands on Wednesday evening, in a game played behind closed doors at the Estadio Algarve.
Substitute Kevin Nisbet then tapped in from close range to score his first goal for the national side just after the hour mark, and just as the Scots looked like they were to hold on for a famous win, a brilliant free-kick from Depay levelled the scores in the 89th minute.
Scotland midfielder John Fleck had tested positive for coronavirus earlier in the week, which forced him and six other squad members into self-isolation.
Clarke still named a strong side for their match with the Netherlands, which showed their mettle and proved that they can be competitive on the European stage.
The Scots have now lost just two of their last 15 international matches across all competitions and head into their clash with Luxembourg having won three and drawn one of their four meetings against them.
Unlike Scotland, Luxembourg will not be heading to Euro 2020, but will still be looking to claim a victory on home soil this Sunday before they return to action in September.
Their most recent international match saw the Red Lions narrowly lose 1-0 away in Norway, with Borussia Dortmund star Erling Braut Haaland scoring a 92nd-minute winner, one of just two attempts that managed to hit the target in the entire game.
It has been nearly 110 years since Luxembourg played their first ever international match, losing 4-1 against France in 1911. During this period, they have only ever faced Scotland on four occasions, losing their most recent encounter 2-1 in November 2012.
Luc Holtz's side have shown signs of improvement over the last year, particularly in a recent game against the Republic of Ireland on March 27, in which they claimed a 1-0 victory, with Gerson Rodrigues scoring an 85th minute winner at the Aviva Stadium.
Just three days later, Luxembourg came close to causing a huge upset against the current European Championship holders Portugal, when Rodrigues again scored the opening goal, before strikes from Diogo Jota, Cristiano Ronaldo and Joao Palhinha ensured the Selecao avoided an embarrassing loss to a nation ranked 96th in the world by FIFA.
The Red Lions will be looking to continue their gradual rise on the international stage with a positive result at the Stade Josy Barthel, and are sure to put up a fight against Scotland on Sunday.
Six of the seven Scotland players who have been self-isolating – David Marshall, Stephen O'Donnell, Nathan Patterson, Grant Hanley, John McGinn and Che Adams – have returned to first-team training and will be available to feature this weekend, however Fleck remains in self-isolation at their training camp in Alicante.
Winger Ryan Fraser was an injury doubt for the match with the Netherlands in midweek but was able to come off the bench for the final 30 minutes and will be in contention to play on Sunday.
After scoring against the Dutch, Nisbet could be handed a start up front alongside either Lyndon Dykes or Adams, while Scott McTominay – who was an unused substitute – could be given a start in either central midfield or as part of the back three.
As for Luxembourg, 21-year-old winger Vincent Thill has been unable to make the squad during the international break, having missed the final part of the season for Portuguese side Nacional through injury.
Striker Daniel da Mota, who received his 100th international cap for the Red Lions in midweek, is likely to partner Rodrigues up front.
Luxembourg possible starting lineup:
Moris; Da Graca, Jans, Mahmutovic, Carlson, Pinto; S. Thill, Martins Pereira, O. Thill; Da Mota, Rodrigues
Scotland possible starting lineup:
Marshall; Hanley, Cooper, Tierney; O'Donnell, Gilmour, McGinn, McGregor, Robertson; Adams, Nisbet
We say: Luxembourg 0-2 Scotland
With little riding on this fixture for Luxembourg, they can play without any real pressure, while Scotland will be hoping they can head into Euro 2020 on a high with a win on Sunday.
The hosts may prove to be a challenging opponent and difficult to break down, but we feel that the Tartan Army should have enough quality to find the net and claim a victory.