While Schalke are now out of the race to qualify for the Europa League, David Wagner will be desperate to end the season on a high after a prolonged run without a victory.
Heading into their meeting with Borussia Monchengladbach in midweek, Wolfsburg would have been confident of getting back on track with their hosts struggling for options in the final third.
However, Oliver Glasner's team were thoroughly outplayed by their Champions League-chasing opponents, leaving his own side under pressure to respond in their final two games.
Due to their superior goal difference, beating Schalke and champions Bayern Munich on the last day of the season will almost certainly be enough to guarantee Europa League football next season.
That said, it is that fixture with Bayern which places even more importance on a maximum return being achieved on Saturday against opponents who are badly out of form.
Glasner will no doubt be hoping that Wout Weghorst can get back on the goal trail, having netted three times in two games before the setback at Monchengladbach.
With European qualification now out of the question, Wagner will simply want Schalke to record a victory by any means necessary before the end of the season.
Schalke have not put together a winning performance in normal time since beating Monchengladbach on January 17, a run stretching 16 matches in all competitions.
Although an extra-time triumph was registered in the DFB-Pokal, Schalke have lost their way, putting Wagner at risk of losing his job in the dugout.
Unless they prevail against Wolfsburg or Freiburg, Die Konigsblauen may finish as low as 14th, the same spot where they ended the last campaign.
Schalke 04 Bundesliga form: LLLDDL
Wolfsburg Bundesliga form: LWLWDL
Schalke could hand an immediate recall to Daniel Caligiuri, who is available again after a one-match ban.
However, Wagner will be without Can Bozdogan after his sending off against Eintracht Frankfurt earlier this week.
Wolfsburg also have issues with suspension after Josuha Guilavogui picked up his fifth yellow card of the campaign.
The visitors are boosted by the return of Renato Steffan, though, and he should line up on the right-hand side of midfield.
Yannick Gerhardt is expected to feature with the aid of a facial mask.
Schalke 04 possible starting lineup:
Nubel; Kenny, Oczipka, Kabak, Miranda; Caligiuri, Schopf, McKennie, Matondo; Boujellab, Raman
Wolfsburg possible starting lineup:
Casteels; Mbabu, Pongracic, Brooks, Roussillon; Steffen, Arnold, Gerhardt, Schlager; Brekalo; Weghorst
We say: Schalke 04 1-3 Wolfsburg
In theory, this is the perfect fixture for Wolfsburg to get back on the right track, and we expect them to do just that. Although Schalke may improve from their last outing, the home side have lost any momentum which they had built from two draws in a row.