The visitors are currently 18th in the table, one point behind 17th-placed Genoa, while Sassuolo occupy 12th position and recorded an impressive 3-1 win at Fiorentina on Wednesday night.
Ten wins, seven draws and 12 defeats - that is how Sassuolo have performed in Serie A during the 2019-20 campaign, with a total of 37 points leaving them in 12th position in the table.
The Black and Greens have been present in each of the last seven Serie A campaigns and only an incredible turn of events would see them dragged into trouble at this stage.
Indeed, they are currently 12 points clear of the bottom three and actually just two points behind ninth-placed Cagliari, suggesting that they are looking up the division rather than down at this stage.
Roberto De Zerbi's side suffered a 4-1 defeat to Atalanta BC on their return to action on June 21, before picking up points in back-to-back draws with Inter Milan and Hellas Verona.
Sassuolo will enter this weekend's match off the back of a victory, though, having impressively won 3-1 at Fiorentina on Wednesday night, with French forward Gregoire Defrel netting a brace.
Lecce earned promotion back to the top flight courtesy of finishing second in Serie B last season, but they are facing a battle to retain their status at this level of football.
I Giallorossi have only picked up 25 points from their 29 league matches during the 2019-20 campaign, which has left them in 18th position in the table, one point behind 17th-placed Genoa.
Fabio Liverani's team won three straight games between February 2 and February 15, but their form immediately before and after the restart will certainly be concerning for their supporters.
Indeed, they have lost each of their last five in Italy's top flight, including defeats to AC Milan, Juventus and Sampdoria since returning to action on June 22.
Lecce played out a 2-2 draw with Sassuolo in the reverse match earlier this season, but the strugglers need to start putting victories on the board if they are to fight off the threat of relegation.
Sassuolo Serie A form: LWLDDW
Lecce Serie A form: WLLLLLL
Francesco Caputo, who has scored 14 times in Serie A this season, is also likely to return despite Defrel netting a brace last time out.
As for Lecce, Fabio Lucioni is available after serving a one-game suspension against Sampdoria on Wednesday night, but Zan Majer, Alessandro Deiola, Gianluca Lapadula and Cristian Dell'Orco are still injured.
The absence of leading scorer Lapadula, who has netted seven times in Serie A this term, is a big one for the visitors, and Antonin Barak could again be deployed in an advanced area in an attempt to fill the void.
Sassuolo possible starting lineup:
Pegolo; Muldur, Chiriches, Ferrari, Rogerio; Magnanelli, Locatelli; Boga, Duricic, Berardi; Caputo
Lecce possible starting lineup:
Gabriel; Rispoli, Donati, Lucioni, Paz, Calderoni; Mancosu, Tachtsidis, Barak; Falco, Saponara
We say: Sassuolo 2-0 Lecce
Lecce's recent form is extremely poor, but Sassuolo will enter the match off the back of a fine result. The home side have a lot of talent in the final third of the field, and we fancy them to pick up all three points here.