Sao Paulo are in the hunt for a Copa Sudamericana spot, currently sitting in 13th in the Brasileiro just outside the top 12 on goal difference, while Corinthians have aspirations to finish this campaign securing a Copa Libertadores place, currently sitting in sixth.
Hernan Crespo's side would have broken into the top 12 by this stage of the season had they turned some of their most recent draws into three points, having picked up just one point from each of their last six games.
During those six games, three outings have ended as goalless draws and the other three matches have concluded in 1-1 draws, and that continued most recently against Ceara.
Sao Paulo fell behind last time out but Jonathan Calleri rescued a point for the home side when he equalised in the 52nd minute; however, Crespo may have felt his side could have taken more points from that game having registered eight shots on target.
Only Cuiaba have drawn as many matches as Sao Paulo this season, but the Tricolor have continued their chase for a top-12 finish and, with 12 Brasileiro matches still to play, they have plenty of time to leapfrog some of the teams above them.
Crespo's team have only lost twice at home this season and are currently on a 10-game unbeaten run in all competitions at the Estadio do Morumbi, suggesting that the hosts will be a difficult outfit to beat on Tuesday.
The team faced with that challenge is Sao Paulo's city rivals Corinthians, who have only lost once in their last 12 league outings, and they bounced back from that defeat with a 1-0 win last time out.
That 69th-minute strike was the only shot that Corinthians managed on target, but that was enough to ensure the side avoided back-to-back defeats for the first time since July.
The Timao are at risk of dropping out of the Copa Libertadores qualification spots as Internacional are only one point behind them and have a game in hand on sixth spot, meaning that Corinthians need to keeping winning to not allow the chasing pack any more advantage.
In the reverse fixture earlier in the season, Corinthians and Sao Paulo played out a goalless draw in quite an evenly-matched contest, but historically Corinthians have had the edge over their rivals in the Classico Majestoso.
Sao Paulo centre-back Miranda picked up his sixth yellow card of the league season on Thursday, meaning that he is suspended for Tuesday's derby fixture.
Considering that Crespo's side have only scored three goals in their last six outings, goalkeeper Tiago Volpi has been vital in ensuring his side did not lose any of those matches, and he is still in the hunt for the Golden Gloves at the end of this season.
The visitors were dealt a big blow on Thursday when Willian was forced off the pitch just nine minutes into that match against Fluminense, and he will be absent from the matchday squad for Corinthians' next few games.
Gustavo Mosquito has not started for Sylvinho's side since 13 September, but the 24-year-old is expected to be given his opportunity from the first whistle on Tuesday as he replaces Willian in the starting lineup.
Sao Paulo possible starting lineup:
Volpi; Reinaldo, Leo, Alves, Orejuela; Lizeiro; Sara, Benitez, Gomes; Calleri, Neves
Corinthians possible starting lineup:
Cassio; Santos, Gil, Victor, Piton; Cantillo; Mosquito, Augusto, Giuliano, Pereira; Guedes
We say: Sao Paulo 0-1 Corinthians
Sao Paulo have not been involved in very high-scoring games recently, and with the hosts having not won a game since last month, Corinthians should enter Tuesday's derby with some confidence to take advantage of that.
After a good victory against a fellow top 12 side last time out, another three points for the visitors will help them keep the pressure on Internacional to catch them.